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Michael Carrick's Manchester United beat Manchester City 2-0 on Saturday, dealing a huge blow to their neighbours' title hopes, as sorry Tottenham slipped to defeat against relegation-threatened West Ham.
Liverpool were held to a 1-1 draw by lowly Burnley while Liam Rosenior celebrated his first league win in charge of Chelsea.
The early result at a bouncing Old Trafford left Pep Guardiola's City six points behind Arsenal, who could extend their lead when they visit struggling Nottingham Forest in the late kick-off match.
Former United midfielder Carrick was the man in the hot seat after being appointed as manager of the Red Devils until the end of the campaign following the sacking Ruben Amorim.
Carrick, who was also briefly United's caretaker manager in 2021, said ahead of his first game that there was still "magic" at United and his team put on a memorable show on home turf.
Second-half goals from Bryan Mbeumo and Patrick Dorgu capped a dominant display by United, who have had to play second fiddle to neighbours City for more than a decade.
The home side also had three goals ruled out for offside, while Gianluigi Donnarumma was inspired in City's goal.
"Great start. No getting away from that," said Carrick. "The boys were fantastic."
"Consistency is the key to any success," he added. "If you could find that, then you're onto a winner.
"That's our challenge -- we've got to find a way to do that. Big one next week obviously (against Arsenal), another tough one, but on the back of today, we've got a good foundation."
Guardiola admitted that his team -- winless in four league games this year -- were outplayed by Carrick's inspired United.
"The better team won," said the City boss. "We weren't at the level required to win this game.
"In many departments, we weren't there. They were better. They had an energy we didn't have."
- Sorry Spurs -
The mood at Tottenham darkened further after Spurs slipped to a 2-1 defeat against West Ham, who had not won a Premier League match since early November.
Crysencio Summerville put the away side ahead in the 15th minute with a deflected strike past Guglielmo Vicario.
Cristian Romero headed home Pedro Porro's cross from the right in the second half to level but substitute Callum Wilson grabbed a stoppage-time winner -- sparking loud boos at the Tottenham Hotspur Stadium.
Spurs have now won just two of their league games at home this season, leaving manager Thomas Frank, in his first campaign in charge, under huge pressure.
Defending champions Liverpool are now unbeaten in 12 games in all competitions but dropped two valuable points against lowly Burnley at Anfield.
Germany midfielder Florian Wirtz scored his third Premier League goal of the season but the visitors improved in the second half and drew level in the 65th minute when Marcus Edwards placed his shot beyond the reach of Alisson Becker.
Chelsea boss Rosenior, who replaced the departed Enzo Maresca this month, watched as his side saw off high-flying London rivals Brentford 2-0.
Joao Pedro gave the Blues the lead in the first half and Cole Palmer doubled the advantage from the spot in the 76th minute.
Sunderland beat Crystal Palace 2-1 while Leeds scored late to beat Fulham 1-0.
S.Yamamoto--JT